Format:

Author:

Annan, Kodwo

Title:

Mathematical modeling of solute transfer during hemodialysis

Dept./Program:

Mathematics

Year:

2009

Degree:

PhD

Abstract:

In an attempt to improve the quality and efficacy of Hemodialysis (HD) treatment many clinical and experimental approaches have been used to investigate solute transfer inside and across hemodialyzer membranes. However, these clinical and experimental protocols are expensive, time consuming, and often culminate in variable results. In addition, these experiments do not take into account the exchange of buffering (Bicarbonate HCO₃⁻) inside the dialyzer and therefore fails to describe fully and predict HCO₃⁻ dynamics across the membrane. Since flow distribution and HCO₃⁻ effect on solute transfer is indispensable for assessing and optimizing HDYs efficiency, we develop mathematical model to quantify solute transfer in HD with HCO₃⁻ dialysate.